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If patients require additional treatment, they may opt for biologics or other immunomodulatory therapies such as anakinra, tocilizumab, or baricitinib [19]

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On the other hand, 20 patients (4 males and 16 females, with the age of 41.0 14.1 and 42.9 12.0 years old, respectively) with major depressive disorders were selected as the research objects, and it was found that L-theanine (250 mg/day) treatment for 8 weeks was safe and effective to significantly mitigate the symptoms of depression, anxiety, somnipathy, and cognitive disorder (67)

Role of short-chain fatty acids in host physiology