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Naltrexone/bupropion (Mysimba) is contraindicated in uncontrolled hypertension, whilst GLP-1 medications like liraglutide and semaglutide require monitoring and specialist supervision as per NICE guidance for patients with cardiovascular risk factors

Significant decrease in alcohol use disorder symptoms secondary to semaglutide therapy for weight loss: a case series

The key difference is that Wegovy is dosed higher and specifically approved for chronic weight management, while Ozempic is primarily indicated for type 2 diabetes management

Weight, mobility or confidence barriers may have made running feel intimidating