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The Lancet dementia commission has reviewed modifiable risk factors that collectively could prevent a significant fraction of dementia cases

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Those target genes include heme oxygenase 1 (HMOX-1), the main regulator of iron and heme metabolism (Suzen et al., 2022), NAD(P)H quinone dehydrogenase 1 (NQO-1), a reducer of ROS (quinones) (Ross and Siegel, 2021), and peroxiredoxin (PRX), which reduces peroxides (Chowdhury et al., 2009), among many others

Dis Esophagus 37(6), 2024