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Collectively, NAD + exerts its effects not through traditional receptor binding but through its indispensable role as a co-substrate and regulator of these enzymatic systems, which sense and respond to fluctuations in NAD + levels to coordinate cellular metabolism, survival, DNA repair, signaling, and cell fate decisions 1-4

A Therapeutic Use Exemption (TUE) was not applicable to this Non-Approved Substance

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or (3) via self-reported weight measurements from the at-home digital scale of the MDPP beneficiary (89 FR 98046)