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Adequate copper status is necessary for optimal DAO activity. Magnesium: Involved in hundreds of enzymatic reactions, including those supporting methylation and overall inflammatory balance. Zinc: Supports toxic histamine aldehyde clearance, which is essential for full clearance of histamine. Glutathione: Acts as your body's master antioxidant that helps modulate mast cell activity

In 2003, a Cochrane review of three RCTs on cognitive function in patients with AD or other forms of cognitive impairment also found no evidence of benefits of B12 on cognitive function compared with placebo

Sci China Ser C 52(6):501505 Acknowledgements We would like to express our gratitude to Lembaga Pengelola Dana Pendidikan, and the Ministry of Finance Indonesia for the BUDI-DN scholarship supporting our study

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