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[PMC free article: PMC4852176] [PubMed: 27199894] 204

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In in vitro systems and animal studies, modulation of these interactions has been employed to investigate cell adhesion, migration, angiogenesis-related signaling, and tissue remodeling mechanisms under experimental conditions

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There are direct and indirect correlations between disease progression and response to therapeutic agents, respectively, with IL-6 levels [33]

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