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Silent information regulator 1 (Sirt1), an anti-inflammatory and anti-oxidative protein (316), increases the production of NO by activating endothelial NOS (eNOS) in endothelial cells in response to shear stress (317)

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First, GSHee elicited a sustained increase in Ve via the sustained increase in fr that was accompanied by the expected decreases in both Ti and Te, whereas it had minimal effects on Vt