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112, 202 There have been several studies showing expression of muscle actin proteins in melanoma with up to 52% of desmoplastic melanomas being positive
Because of their glucose lowering effects, therapies that enhance incretin actions through inhibiting degradation of endogenous incretins or through activation of the GLP-1 receptor are now in use for the treatment of type 2 diabetes ( ATP channels and in postprandial hypoglycemia after gastrointestinal surgery, where the delivery of nutrients to the small intestine is altered resulting in both hyperglycemia and an exaggerated secretion of GLP-1
The closest human data is from CB4211, an analog that completed a Phase 1a/1b safety trial (NCT03998514) with well-tolerated SubQ dosing and favorable liver-enzyme and glucose trends
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