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GLP-1 signaling also directly downregulates proinflammatory cytokines in mucosal immune cells (55), consistent with a targeted hierarchy of mechanisms that prioritizes epithelial defense and local immune modulation over systemic immunosuppression

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Contact your GP if you experience: Headaches that dont respond to over-the-counter painkillers Headaches lasting more than three days continuously A significant change in headache pattern or a new type of headache Headaches that worsen when lying down, coughing, or straining Headaches accompanied by persistent vomiting that prevents you from staying hydrated Feelings of anxiety or low mood related to your symptoms Seek urgent medical attention (call 999 or go to A&E) if you experience: A sudden, severe headache that reaches maximum intensity within minutes Confusion, drowsiness, or difficulty speaking Visual disturbances (blurring, double vision, or loss of vision) Weakness or numbness, especially on one side of the body A headache with fever and stiff neck These warning signs are not specific to Wegovy but apply to any new or severe headache