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Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases

Result: Microbial imbalance in asthma patientsmarked by reduced -diversity, depletion of immunomodulatory taxa (e.g., Bifidobacterium, Faecalibacterium), and enrichment of pathobiontsdisrupts short-chain fatty acid (SCFA) and tryptophan metabolism, skewing Th17/Treg balance toward Th2-dominated inflammation and airway hyperresponsiveness