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Type 1 diabetes History of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 Chronic severe gastrointestinal disease or gastroparesis Prior pancreatitis Severe kidney disease Eye disease, such as active proliferative diabetic retinopathy Known hypersensitivity to the medication Pregnancy or breastfeeding Which Lifestyle And Drug Factors Can Make A Heart Rate Rise Worse Several common factors can push resting heart rate higher while on semaglutide