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Abbreviations IL-1: Interleukin-1 IL-2: Interleukin-2 IL-4: Interleukin-4 IL-6: Interleukin-6 IL-7: Interleukin-7 IL-8: Interleukin-8 IL-10: Interleukin-10 IL-12: Interleukin-12 IL-15: Interleukin-15 IL-17: Interleukin-17 IL-18: Interleukin-18 IL-20: Interleukin-20 IL-21: Interleukin-21 IL-22: Interleukin-22 IL-23: Interleukin-23 IL-27: Interleukin-27 IL-33: Interleukin-33 IL-37: Interleukin-37 GM-CSF: Granulocytemacrophage colony-stimulating factor MIG: Monokine induced by gamma IP-10: Interferon gamma-induced protein 10 TGF-1: Transforming growth factor-beta 1 TNF-: Tumour necrosis factor-alpha IFN-: Interferon-gamma JAK/STAT: Janus kinase/signal transducer and activator of transcription SMAD2/3: Suppressor of mothers against decapentaplegic 2/3 NLRP3: Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 TIMP2: Tissue inhibitor of metalloproteinases 2 PCNA: Proliferating cell nuclear antigen SOCS3: Suppressor of cytokine signalling 3 FVWFs: Female vaginal wall fibroblasts BMSCs: Bone marrow mesenchymal stem cells MDSC: Myeloid-derived suppressor cells PCL/PLGA-BCP: Polycaprolactone/poly(lactide-co-glycolide) biphasic tricalcium phosphate References ACOG Practice Bulletin No

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Meningococci may be able to invade epithelial cells in areas where the mucus layer is interrupted possibly due to inflammation or the activity of the resident microbiota that is able to attack the mucus, for instance by hydrolysis of glycans ( Streptococcus anginosus , S