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However, Dihexa remains entirely preclinical, and its foundational research has faced serious integrity concerns including an expression of concern and a retraction on key papers

Future research should aim to delineate critical windows of vulnerability, elucidate the underlying biological mechanisms, and determine whether targeted nutritional or metabolic interventions during pregnancy can attenuate these adverse outcomes

Gorman, GS, Chinnery, PF, DiMauro, S, Hirano, M, Koga, Y, McFarland, R, Suomalainen, A, Thorburn, DR, Zeviani, M, Turnbull, DM 2016, Mitochondrial diseases, Nature Reviews Disease Primers , vol

The recent development of more complex therapies and the extension of interest in the domain of senescence in different fields of research allow to extend the possibility to discover powerful therapies