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Cancer Inst

If the chronic cerebral hypoperfusion hypothesis is correct then brain neuronal accumulations of A1-42 and tau proteins must be considered downstream consequences rather than causes of AD [48]

When mitochondrial damage excessively accumulates and the organelle is irreversibly damaged, mitophagy is initiated to remove harmful substances and the entire damaged mitochondrion through the lysosomal pathway thereby maintaining organelle health to ensure that the overall state of the cell is not negatively affected

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