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Advancing neuroscience and therapy: Insights into genetic and non-genetic neuromodulation approaches

DSIP also modulates the hypothalamicpituitaryadrenal (HPA) axis, lowering nighttime cortisol spikes and reducing stressrelated arousal, which contributes to more stable circadian rhythms Peptide therapy for sleep has an excellent safety profile when administered under qualified medical supervision, with minimal side effects and no dependency risk

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The variable results in animal studies may be due to the differences in diabetic models and might also depend on the time scale of the experiments and the limitations of the methods used to measure the permeability of the BBB