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Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism

While constipation can be an ongoing challenge with GLP-1s, most people find that simple habits like hydration, fiber, and movement are enough to keep it under control

Because this side effect occurs consistently, it has led to interest in topiramate for obesity, but the risks associated with the drug make off-label use for weight loss inappropriate outside specialist settings

Some healthcare providers prescribe it off-label for this purpose, despite it not having official FDA approval for weight loss