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The indication for prophylactic pharmacotherapy depends on attack intensity (more than every 12 months) and severity (exceeding 2 days or requiring hospitalization), the impairment of the QoL (e.g., frequent school absences) and if attack treatments are ineffective or cause side effects

Animal studies were performed in keeping with the principles put forth by the Experimental Animals Management Committee

The peptide upregulates tyrosinase, but the enzyme requires UV-induced oxidative stress to catalyze melanin polymerization

It supports muscle growth and repair by providing the necessary building blocks for protein synthesis