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doi: 10.1177/002215540305100513 69 BrodersenDENyborgJKjeldgaardM

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-arrestins were first recognized for desensitizing GPCRs by uncoupling them from G-proteins and promoting receptor internalization via clathrin-coated pits, but are now known to act as signaling scaffolds themselves, initiating distinct pathways like ERK, JNK, or NF-B activation

Wear loose-sleeved clothing for easy access to your arm, and plan for about one hour total including setup, infusion, and brief post-treatment monitoring