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Nature 330 , 537543 (1987)

It was first synthesized and studied by Sikiric and colleagues at the University of Zagreb in the 1990s, almost entirely in rodent and small-animal models.[7] The theoretical relevance to PCOS centers on three preclinical properties: reduction of systemic and gut inflammation, promotion of angiogenesis and tissue healing, and modulation of dopaminergic and serotonergic signaling

Overall, 7% of participants in the Wegovy pill trial stopped treatment because of side effects, versus 6% on placebo

Funding Open access publishing supported by the institutions participating in the CzechELib Transformative Agreement