1492-C ALANINE AMINOTRANSFERASE TO QUANTITATIVE HBsAg RATIO INDEPENDENTLY PREDICTS LONG-TERM HBsAg SEROCLEARANCE AFTER ENTECAVIR CESSATION IN CHINESE HEPATITIS B PATIENTS Ryan Hin-Man Leung 1 , Rex Wan-Hin Hui 1 , Lung Yi Mak 1,2 , Kevin Sze Hang Liu 1 , Danny Ka-Ho Wong 1,2 , James Fung 1,2 , Wai-Kay Seto 2,3,4 and Man-Fung Yuen 2,5 , (1)Department of Medicine, School of Clinical Medicine, the University of Hong Kong, Hong Kong SAR, (2)State Key Laboratory of Liver Research, the University of Hong Kong, Hong Kong SAR, (3)Department of Medicine, School of Clinical Medicine, the University of Hong Kong, (4)Department of Medicine, the University of Hong Kong-Shenzhen Hospital, Shenzhen, China, (5)Department of Medicine, Queen Mary Hospital, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, Hong Kong, China Background: Nucleos(t)ide analogue cessation in chronic hepatitis B (CHB) may induce hepatitis B surface antigen (HBsAg) seroclearance
The gamma-glutamyl cycle should be considered not as a mechanism for amino acid transport but rather a generator of extracellular signals, gamma-glutamyl amino acids, that are converted intracellularly to 5-oxoproline, which activates uptake and/or metabolism of amino acids (1, 74, 75)
J., Lo Bello, M
The spent variant arises after the molecule has performed its function
