phentermine vs tirzepatide GLP-1: how the two biggest weight loss medication classes compare Phentermine vs Semaglutide vs Tirzepatide

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The STEP 1 trial showed semaglutide 2.4 mg led to 14.9% weight loss over 68 weeks, while SURMOUNT-1 showed tirzepatide achieved up to 20.9% weight reductionapproaching bariatric surgery outcomes.[6] The SELECT trial (17,604 patients) found semaglutide reduced cardiovascular death, non-fatal heart attack, and non-fatal stroke by 20% and all-cause mortality by 19%, suggesting direct cardioprotective effects beyond weight loss.[4] In STEP-HFpEF, semaglutide produced 13.3% weight loss in heart failure patients and improved symptoms and physical function

[DOI] [PubMed] [Google Scholar] 83.Ascione R., Rogers C.A., Rajakaruna C., Angelini G.D