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Biguanide-derived neuroprotective agent (metformin) To mitigate neuroinflammation and mitochondrial dysfunction in PD, metformin was encapsulated into PLGA, which were further coated with BV2 microglial cell membranes to enhance the targeting efficiency to neuroinflammatory sites (BV2-metformin-loaded PLGA) for intranasal administration 19
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