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However dulaglutide doses greater than 0.5 mg/kg were demonstrated to increase hyperplasia of thyroid C cells ( These data suggest that rodents are particularly sensitive to the effects of GLP-1 agonists on thyroid C cells but these foindings could not be considered as predictive of an increased risk of thyroid C-cell tumors in patients under GLP-1 receptor agonist therapy ( Insulin Insulin is a widely prescribed glucose-lowering agent (Sims et al., 2021) especially in patients affected by type 1 diabetes mellitus (T1DM) as well as in some patients with Type 2 diabetes mellitus

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