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Macrophages contribute to renal fibrosis through the tyrosine kinase Src, which activates both the TGF-1/SMAD3 and JAK/STAT pathways to promote MMT (89)

Both the monitoring of OTA and the diagnosis of OTA-induced mycotoxicosis in humans rely on blood and urinary OTA levels

Researchers from another center also added that almost always at the time of revision laparotomy, signs of aseptic peritonitis with an exudative or fibroplastic reaction are observed in the abdominal cavity ( 38 )

Based on these researches, clinical trials targeting HO-1 should be carried out to evaluate its application in the treatment of DN, so as to provide evidence for clinical application