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Extracellular cystine deprivation increases ROS generation and inhibits NADPH oxidase 4 (NOX4), which inhibits ferroptosis by antioxidation, therefore inducing cell death in human mammary epithelial (HME) cells harboring an EGFR mutation (Poursaitidis et al., 2017)

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QiShenYiQi is a Chinese herbal formulation derived from various herbs, including Radix astragali, Salvia miltiorrhiza, and Panax notoginseng has the potential to treat renal fibrosis in obstructive nephropathy by reducing -smooth muscle actin, TGF-1-responsive collagen I, and fibronectin upregulation [55]