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However, here are two emerging theories as to why Mounjaro causes fatigue and tiredness: 1 Mounjaro may lead to very low-calorie intake: This will cause the body to slow down metabolism to preserve existing energy stores

Journal of Critical Care

By enhancing feelings of fullness , GLP-1 effectively helps to control appetite, which is essential for successful long-term weight loss and improving metabolic health

In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)