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Danuglipron made it further to Phase IIb, but Pfizer ended the entire program in April 2025 after a single asymptomatic case of potential drug-induced liver injury and dropped its third oral candidate a few months later

It primarily affects women of childbearing age who are overweight

GLP-1 medications may be considered for patients who: Struggle with appetite control despite lifestyle efforts Have weight-related health concerns Require medical support for weight management under supervision Suitability depends on: Medical history Current health conditions Medications and risk factors A consultation with our doctors is required to determine if GLP-1 medication is appropriate