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"Guideline on the Manufacture of the Finished Dosage Form." EMA/CHMP/QWP/245074/2015.

However, because of their low plasma and brain concentrations, it is unlikely that they contribute significantly to the anticonvulsant effects of VPA [10]

In the phase 3 trial, outcomes measured at 20 weeks showed that most participants could get the total amount, losing weight as their dose was increased