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The same gastrointestinal side effects, central adaptations, and pleiotropic actions that once discouraged development are now recognized as manageable features of peptide pharmacology when appropriately contextualized

Over the last decade, although the prescription of GLP-1 RAs has increased slightly, overall usage remains low compared with other glucose-lowering medications, such as metformin, sulfonylureas and dipeptidyl peptidase 4 inhibitors (DPP4i), regardless of CV disease status [30,31,32,33]