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Chronic exposure to PET MPs (0.5400 m, majority 50100 m) over 29 weeks at a dose of 5 mg/week (approximating the relevant annual intake in humans) was investigated in C57BL/6 N mice from peripubertal age to adulthood

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Key hormones involved in appetite control include: Ghrelin : Often referred to as the "hunger hormone," ghrelin stimulates appetite and increases food intake

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AF was the most potent inhibitor of TGR, with IC 50 values in the low nanomolar range

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