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In an effort to investigate whether NMN treatment would have an impact on the health of UMNs diseased with TDP-43 pathology, we utilized dissociated motor cortex cultures established from prpTDP-43 A315T -UeGFP mice, in which CSMN are genetically labeled with eGFP expression that is stable and long-lasting, and when in culture retain their CSMN identity and eGFP expression

In addition, compared with cleavable linker conjugates, it is expected to reduce off-target toxicity, since the non-cleavable ADCs can provide greater stability and tolerance

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Singh, Evaluation of oxidative stress before and after control of glycemia and after vitamin E supplementation in diabetic patients, Metabolism