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Adjusting Frequency Based on Response The dose frequency might change based on how a patient responds

The blocking of the lysosomal iron translocation of CSCs by inhibiting the divalent metal transporter 1 (DMT1) leads to iron accumulation and cell death with features of ferroptosis (Turcu et al., 2020)

Las reacciones adversas notificadas con mayor frecuencia durante los estudios clnicos fueron trastornos gastrointestinales, como nuseas (muy frecuentes), diarrea (muy frecuentes) y vmitos (frecuentes)

Allopurinol is the first-line ULT, typically started at 100mg daily and titrated to achieve target serum uric acid levels below 360 mol/L (or below 300 mol/L in people with tophi)