In clinical trials, less than 1% of people taking semaglutide reported experiencing constipation
OTC laxatives, stool softeners, and fiber supplements can safely relieve your constipation while on semaglutide
Semaglutide Not Associated with Increased Risk of Eye Disorders, 19 August 2025, The use of semaglutide medicines and risk of non-arteritic anterior ischemic optic neuropathy (NAION), 27 June 2025, WHO, PRAC concludes eye condition NAION is a very rare side effect of semaglutide medicines Ozempic, Rybelsus and Wegovy, 06 June 2025, European Medicine Agency, Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan, does semaglutide increase the risk of non-arteritic anterior ischemic optic neuropathy
Clinical Studies and Evidence SUSTAIN-6 Trial (Cardiovascular Outcomes) Published in the New England Journal of Medicine (2016), the SUSTAIN-6 trial demonstrated that Semaglutide significantly reduced the risk of major adverse cardiovascular events (MACE) cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke by 26% compared to placebo in patients with Type 2 diabetes and high cardiovascular risk
