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A total of 177 natural products with greater potential for AD treatment were screened by mapping the target gene set of each natural product to the constructed network, yielding 177, 103, and 29 natural products from Most Studied Pathways, Gene-Associated Pathways, and Popular Pathways, respectively (Additional file 1: Table S7)

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NNMT is a cytosolic enzyme that is primarily expressed in the liver and catalyzes the transfer of methyl group from the cofactor S-(5-adenosyl)-L-methionine (SAM) to other substrates