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FDA Food and Drug Administration, GI gastrointestinal, N/A not applicable, SNAC sodium N-(8-[2-hydroxylbenzoyl] amino) caprylate a Indications and approval are per United States FDA Icotrokinra Description and Review of Available Data Icotrokinra is a chemically synthesized cyclic peptide (molecular weight, 1.9 kDa) that binds selectively to the IL-23R, thereby blocking IL-23 signaling and the subsequent production of downstream cytokines, including IL-17A, IL-17F, and IL-22 [80] (Fig

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