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This may be mediated mainly by activating proopiomelanocortin neurons, which, in turn, activate hypothalamic melanocortin 4 receptors (MC4R) that receive projections of POMC fibers, responsible for the anorexigenic activity [130,131]

Regarding trial duration, this ranged between 26 weeks and 56 weeks in all trials except for two, making a subgroup analysis based on duration unwarranted

In short, Wegovy and Ozempic are essentially identical medications under different brand names, with the primary difference lying in the dosage of semaglutide in each injection pen and the specific approvals granted for their use