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The control point from the non-diabetic data this used to condition the asymptotic GSH in the fit was obtained via a GSH versus age linear regression (Figure S14 in File S1) for each individual

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The injectable 500 mg/mL solution bypasses the gut, which sidesteps the absorption-driven GI complaints of oral dosing but injection carries its own generic considerations, the local injection-site reactions (pain, redness, irritation) common to any intramuscular or subcutaneous injection

While these studies involve relatively small groups of participants, their scientific and operational complexity is considerable