Targets like TLR4, TRPV1, BDNF, and NLRP3 along the spinal cord become direct gateways for adaptogenic or neuroprotective molecules
Figure 2 3.1 The metabolism of short chain fatty acids SCFAs, such as acetate (C2), propionate (C3), and butyrate (C4), are produced through the fermentation of dietary fibers and indigestible carbohydrates (such as resistant starch) by the gut microbiome ( Eubacterium , Ruminococcus , Faecalibacterium , and Clostridium clusters IV and XIVa dominate the production of butyrate, while acetate and propionate are associated with Bacteroidetes and Firmicutes ( Studies have found that, compared to healthy relatives, the levels of butyrate in fecal samples from BD patients were significantly reduced and positively correlated with Roseburia (65)
Always inform your healthcare provider of any NSAID use and monitor for new stomach pain, nausea, or dark stools
In another experiment, ezetimibe + simvastatin 10 mg/day prevented a reduction in FMD after a high-fat meal better than simvastatin 80 mg/day alone