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( Bacillus subtilis and rheinan anthraquinone from rhubarb with anti-inflammatory activity (2025) designed an 18-glycyrrhetinic acid prodrug nanomicelle that, when combined with Lactobacillus rhamnosus GG, repaired the intestinal barrier and inhibited microglia-mediated neuroinflammation, thereby alleviating UC and concomitant depressive-like behaviors