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L-Arginine and L-Citrulline have documented interaction profiles with nitrate medications, antihypertensive drugs, and PDE5 inhibitors

Some patients achieve maximal weight loss by 60-72 weeks and then maintain that reduced weight, which represents successful chronic disease management rather than treatment failure

J Transl Med 14:290

Therefore, this report represents the first documented prolonged water fast for a patient with morbid obesity (BMI 40) since 1973, when Angus Barbieri lost 276 pounds (82 kg) over 382 days [10]