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While it showed promising antiproliferative effects in vitro and in preclinical models, combination of triapine with cisplatin-based chemoradiation plus brachytherapy in locally advanced cervical cancer patients with intrinsic ribonucleotide reductase overexpression, did not improve overall survival in a Phase III trial (NCT02466971)

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The tremor is absent in all cases, but many patients report empty hands and fingers rubbing against one another in a movement resembling counting coins. The Role of Physical Exercise & Postural Instability Postural instability is a primary motor symptom in a later stage of shaking palsy