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AOD 9604 showed only 2.6 kilograms of weight loss in its best trial result and failed to demonstrate significant weight loss in six clinical trials overall

Leptin is a trigger for an inflammatory response in skin, so this is perhaps why obesity can trigger more severe psoriasis flares. A separate study last year (6) found that psoriasis patients who were taking glucagon-like peptide-1 receptor agonists for type 2 diabetes showed a significant reduction in PASI scores, which are a measuring scale for the severity of psoriasis, with fewer markers for of inflammation in layers of the skin and reduced auto immune responses

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