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Evaluation of the expression of lung IL-6, IL-4, IL-13, COX-2, and TNF- showed a significant dose-dependent decreases with You-Gui-Wan treatment (1 g/mL, 3 g/mL, 6 g/mL) [165]

A 2018 review by Pickart and Margolina documented that GHK-Cu affects the expression of more than 4,000 human genes (roughly 31 percent of the genome), generally shifting expression patterns toward younger, more regenerative profiles

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The knowledge gained from in vitro , preclinical, and animal studies has encouraged a variety of clinical trials investigating the role of dietary choline supplementation in disease progression ( Table 1 ), as well as the association between circulating choline-containing metabolites and disease prognosis or clinical symptoms ( Table 2 )