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(3) In naturally aged mice, FOXO4-DRI treatment reduced senescent cell burden, improved liver and kidney function, restored exercise tolerance (grip strength and running capacity), and improved coat appearanceall markers of healthier aging

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Tesamorelin is a growth hormone-releasing hormone (GHRH) analog, not a GLP-1 agonist

While several recent trials (e.g., SYNERGIC, PONDER, DO-HEALTH) have attempted to examine multidomain interventions in older adults, most have yielded modest or inconsistent outcomes, particularly regarding vitamin Ds independent or additive benefits