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Frequency: Administer up to two subcutaneous injections daily, such as two hours prior to and after the subject has undergone physical activity

[10] It is plausible, though not yet proven specifically for retatrutide, that combined stimulation of GLP-1 and glucagon receptors could produce a more pronounced elevation in heart rate compared with single or dual agonists

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PubMed PMID: 40005999 Safer et al