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Furthermore, a sulforaphane intervention study in a cohort of healthy participants augmented peripheral and brain glutathione (Sedlak et al., 2017), an antioxidant readily implicated in various neurological functions ( Psychiatric Disorders Due to the supportive mechanistic data, animal models and clinical trials have begun to evaluate the use of sulforaphane interventions for psychiatric outcomes, including depression, schizophrenia, and autism (Panjwani et al., 2018)

In post-mortem patient samples, both messenger RNA (mRNA) and protein levels of NRF2 have been reported to be reduced (Sarlette et al., 2008) and proteomic analysis of spinal motor neurons from humans with SOD1-related ALS had revealed that the NRF2-induced gene peroxiredoxin is transcriptionally repressed (Wood-Allum et al., 2006)