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Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis

Moreover, both Sirtuin-3 and Sirtuin-1 can deacetylate and activate forkhead box class O 3a (FoxO3a), the ubiquitously expressed transcription factors, and then upregulating the genes involved in mitochondrial oxidative defense, such as SOD2 (Jacobs et al., 2008