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When the human autoantibodies were infused into healthy mice, the mice developed neurological features mimicking those of the patients, including fatigue, loss of balance, pain sensitivity, and nerve fiber damage

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Most GLP-1RAs, aside from a new oral formulation of semaglutide (Rybelsus tablets), are administered subcutaneously via pen-like devices (once daily to once weekly) due to poor oral bioavailability, and all are renally excreted 1

The weighted incidence of suicidality was 3.9 and 3.7 for every 1,000 person-years among GLP-1 receptor agonist and DPP-4 inhibitor users, respectively