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The index single-nucleotide polymorphism (SNP) of the main association was rs10305420 ( P = 2.9 10 10 , reference allele C, effect allele T), which conferred an additional 0.641% BMI loss per T allele, approximately equivalent to an additional 0.76 kg weight loss per allele (95% CI, [1.27, 0.34] kg)

Lancet Diabetes Endocrinol 10:774785

Furthermore, the imbalance and/or cellular stress of biological chemicals designed to prevent the damage warned by ROS has been shown to cause damage to DNA, proteins, and lipid layers, reducing embryo development and quality 25,34

Third, the sample sizes of the reported trials were small, which affects the credibility of the results