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Some patients report fewer migraine days within 8-12 weeks of starting therapy, coinciding with initial weight loss and metabolic improvements

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Blood samples of these patients were collected at baseline, week 4, week 12, and week 26

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Biomarkers of insulin resistance and T2D are decreased in PBH

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c Number of sites with a substitution predicted by both SIFT (67) to Affect function and PROVEAN (68) to be Deleterious

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